Lobi Stars began their CAF Champions League campaign with a 2-1 win over Mamelodi Sundowns at the Nnamdi Azikiwe Stadium on Friday.
The 2016 winners Mamelodi Sundowns slipped to a surprise 2-1 defeat against Lobi Stars.
Liberian international Anthony Laffor opened the scoring, but the Pride of Benue restored parity when Yaya Kone converted from the spot on the stroke of half-time, with Samuel Mathias netting the winner shortly after the restart.
In another Group A fixture, 2017 champions Wydad Casablanca got off to a flying start with a 5-2 victory over ASEC Mimosas, with Michael Babatunde on song for the Moroccan giants.
CAF Champions League holders ES Tunis began their defence in underwhelming fashion as a late Anice Badri goal salvaged a 1-1 draw with Horoya.
ES Tunis claimed their third CAF Champions League title by comfortably beating Al Ahly over two legs last November, but were far from convincing in their opening match of Group B.
Reigning Guinean champions Horoya went ahead in the 68th minute through Ocansey Mandela and it looked as though they were heading for an upset win before Badri hauled the visitors level in the 93rd minute.
Bolaji Sakin played for the Guinean side in Conakry.
Elsewhere, CS Constantine claimed a 1-0 win over Club Africain to get their Group C campaign off to a strong start.