Kano Pillars kept their Aiteo Cup dream alive after overcoming Ilorin outfit Kwara United 4-2 on penalties.
Pillars are up against Aklosendi who bundled out EFCC FC in the last eight.
Rivers United will face Lobi Stars, who eliminated Abia Warriors 3-1 in the round of 16.
Smart City who bundled out Enyimba and Shooting Stars should certainly fancy their giant killing chances against Niger Tornadoes.
Bendel Insurance will do battle with Calabar Rovers.
The Nigeria Football Federation (NFF) will confirm venues for the encounters in due course.
Games will take place on Friday 28th June.
Full quarter-final fixtures:
Lobi Stars Vs Rivers United
Niger Tornadoes Vs Smart City
Bendel Insurance Vs Calabar Rovers
Kano Pillars vs Aklosendi