Head coach of Super Eagles, Gernot Rohr has named his eleven-man team to take on South Africa in the Quarter-final clash at the ongoing Africa Cup of Nations (AFCON).
Kickoff at the Cairo International Stadium on Wednesday is 8pm.
The starting XI of Nigeria sees two changes to the side that played against Cameron.
Ola Aina and Moses Simon drop to the bench for Jamilu Collins and tricky Samuel Chukwueze.
The Super Eagles prevailed 3-2 over Cameroon in the second round. However the Eagles were second best for most of that game, and will need to improve to book a semi-final spot.
South Africa may have picked their spot in the round of 16 as one of the four best third placed teams, but they have shown great determination to make it this far after coming through a gruelling 1-0 victory against hosts Egypt.
In defence will be Kenneth Omeruo, Jamilu Collins, William Troost-Ekong and Chidozie.
Wilfred Ndidi, Oghenekaro Etebo and Alex Iwobi.
Odion Ighalo is expected to lead the attack and will be supported by Ahmed Musa and Samuel Chukwueze.
In terms of head to head, the two nations have played each other on 13 occasions. Eagles have the edge with six wins, five draws and two losses.
Super Eagles Starting XI Vs South Africa: Daniel Akpeyi, Chidozie Awaziem, Jamilu Collins, William Troost-Ekong, Kenneth Omeruo, Oghenekaro Etebo, Wilfred Ndidi, Alex Iwobi, Samuel Chukwueze, Ahmed Musa, Odion Ighalo